Study shows UK variant of Covid up to 100% deadlier

Covid-19 coronavirus binding to human cell, conceptual computer illustration. SARS-CoV-2 coronavirus (previously 2019-nCoV) binding to an ACE2 receptor on a human cell (not to scale). SARS-CoV-2 causes the respiratory infection Covid-19, which can lead to fatal pneumonia. ACE2 (angiotensin-converting enzyme 2) is a membrane-bound aminopeptidase, the key host receptor for the spike glycoprotein of SARS-CoV-2 which serves as initial step in the development of coronavirus infection on a cellular level and a potential target for treatment strategy.

The UK variant of the coronavirus disease 2019 (Covid-19) is up to 100 percent more deadly than the original strains of the virus, according to a study published Wednesday by the British Medical Journal.

The B.1.1.7 variant, which was first identified in Kent, England, in September 2020, led to 227 deaths in 54,906 infected patients, the data showed.

In comparison, among a similar population of people sickened with earlier strains of the virus, 141 died, the researchers said.

“In the community, death from Covid-19 is still a rare event, but the B.1.1.7 variant raises the risk,” study co-author Robert Challen said in a press release.

“Coupled with its ability to spread rapidly this makes B.1.1.7 a threat that should be taken seriously,” said Challen, an epidemiologist at the University of Exeter in England.

The variant is more contagious than earlier strains and was the primary reason for the most recent round of lockdowns across Britain, according to the researchers.

It has already been detected in more than 50 countries worldwide, including the United States, the researchers said.

Through Tuesday, just under 3,300 cases of the UK variant had been reported in the United States, according to the US Centers for Disease Control and Prevention.

However, an analysis released by the CDC in January predicted that it would be the “predominant” strain of the virus in circulation nationally by the end of this month.

The study compared death rates among people infected with the new variant and those infected with other strains.

The higher transmissibility of the UK variant meant that more people who would have previously been considered low risk were hospitalized, the researchers said.

With 62 percent more deaths linked with the variant, compared to previous strains, the researchers estimated that it is between 30-percent and 100-percent more deadly than those that originated in China.

“[The coronavirus] appears able to mutate quickly, and there is a real concern that other variants will arise with resistance to rapidly rolled out vaccines,” said study co-author Leon Danon.

“Monitoring for new variants as they arise, measuring their characteristics and acting appropriately needs to be a key part of the public health response in the future,” said Danon, an epidemiologist at the University of Bristol in England.

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